Throughput: 480 tests/hour 580 tests/hour with ISE
Test items on board: 36 items + ISE 3 items
Reaction volume: 120– 300 micro-liter
Patient samples on board: 72 patient samples, 30 STAT samples
Reaction volume: 140– 300 micro-liter
Test items on board: 24 items + ISE 3 items / 36 items + ISE 3 items
Patient samples on board: 30 patient samples
Throughput: 270 tests/hour 450 tests/hour with ISE
R1: 140 ～ 300μl (1μl step）
R2: 20 ～ 260μl (1μl step）
News and Announcements
As multidrug-resistant organisms continue to emerge, specific tests, called antibiotic susceptibility assays, are increasingly critical. Clinicians depend on reliable results when choosing the right drug to treat patients.To determine which antibiotics reliably treat which bacterial infections, diagnostic laboratories that focus on clinical microbiology test pathogens isolated from patients for antibiotic sensitivity. However, a recent study reveals that one aspect of these tests may fall short and not be stringent enough.
Microbiologists at the Beth Israel Deaconess Medical Center (Boston MA, USA) and their colleagues examined pathogens cited by the US Centers for Disease Control and Prevention (Atlanta GA, USA) and the World Health Organization (Geneva, Switzerland) as urgent and concerning drug resistance threats.
To obtain consistently reliable results, scientists conducting antibiotic susceptibility assays follow national guidelines with standardized methods, including the use of a specific number of organisms, or "inoculum" that is added to each assay. There is a target inoculum, and then a range of an allowable inoculum, or acceptable upper and lower bounds around the target inoculum.World Health Organization
The diagnosis of multiple myeloma, a cancer affecting plasma cells, traditionally forces patients to suffer through a painful bone biopsy. Doctors insert a bone-biopsy needle through an incision to get a bone marrow sample or make a larger incision and remove a section of bone via surgery.
However, the days of using bone biopsies to guide treatment for multiple myeloma and other cancers, such as many types of leukemia, may be numbered. A low-cost, reliable blood test that uses a small plastic chip about the size of a credit card that can deliver the same diagnostic information as a bone biopsy, but using a simple blood draw instead.
Scientists collaborating with those at the University of Kansas (Lawrence, KS, USA) took blood samples from patients with plasma cell disorders, which were analyzed for the presence of circulating plasma cells (CPCs) using a microfluidic device modified with monoclonal anti-CD138 antibodies. CPCs were immuno-phenotyped using a CD38/CD56/CD45 panel and identified in 78% of patients with monoclonal gammopathy of undetermined significance (MGUS), all patients with festering and symptomatic multiple myeloma (MM), and none in the controls.University of Kansas
Beta Trace Protein (BTP) is a promising marker of glomerular filtration rate (GFR) as it was reported to be increased in the serum of patients with renal disease. Some evidence suggests that it is more sensitive than creatinine (Cr) at detecting early changes in GFR. Unlike Cr, very little is known about the origin and metabolism of BTP. BTP is a heterogeneous glycoprotein with multiple isoforms and is present in various fluid compartments including blood, urine and cerebral spinal fluid (CSF). The impact of hepatic dysfunction on serum BTP concentrations has recently been investigated.
Scientists at Queen’s University (Kingston, ON, Canada) and their colleagues conducted a case-control study between June to October 2014 of 99 cirrhotic subjects and matched controls. The diagnosis of cirrhosis was confirmed by the hepatologists according to standard clinical criteria including non-invasive testing estimating F4 fibrosis in an individual with known chronic liver disease. Basic demographic, clinical and laboratory data were collected including diabetes status, etiology of cirrhosis, presence of ascites or encephalopathy, INR, albumin and bilirubin. The team measured Cystatin C (cysC), BTP using nephelometry assays and Cr using a Vitros Chemistry enzymatic assay. The BTP/cysC ratio was calculated for each subject. The BTP/cysC ratio was chosen in lieu of the BTP/Cr ratio due to the well-recognized inaccuracy of serum creatinine as a marker of GFR in the setting of hepatic dysfunction.Read More Here
Heart disease remains the leading cause of death in men and women in the USA, and each year 735,000 Americans have heart attacks that damage the heart muscle, and of those, an estimated 120,000 die. About one in five heart attacks are "silent," yielding no symptoms, but symptoms such as chest tightness or pain, dizziness, nausea and fatigue are good reasons to seek immediate evaluation. Among the diagnostic tools to detect heart attacks are blood tests that measure levels of various proteins released into the bloodstream when heart cells are injured. Two of these are cardiac troponin and creatine kinase-myocardial band (CK-MB).
Scientists at the Johns Hopkins University School of Medicine (Baltimore, MD, USA) and the Mayo Clinic (Rochester, MN, USA) have compiled peer-reviewed evidence and crafted a guideline designed to help physicians and medical centers stop the use of a widely ordered blood test that adds no value in evaluating patients with suspected heart attack. The clinical and financial implications of institutions continuing CK-MB testing are significant, say the authors, who estimate that all blood tests for diagnosing heart attacks add USD 416 million each year to the cost of care. The team also cites studies showing that in addition to its diagnostic value, troponin testing is a more definitive predictor of in-hospital mortality and severity of disease. Professional guidelines concluded that CK-MB provides no additional diagnostic value for diagnosing heart attacks. It was found that 77% of nearly 2,000 laboratories in the U.S. still use CK-MB as a cardiac damage biomarker.
Jeffrey Trost, MD, an assistant professor of medicine and the corresponding author of the study, said, “This article is the first in a series of collaborative multi-institutional publications designed to bridge knowledge to high value practice. We present multiple quality improvement initiatives that safely eliminated CK-MB to give providers reassurance about trusting troponin levels when managing patients with suspected acute coronary syndrome.” The study was published on August 14, 2017, in the journal JAMA Internal Medicine.Related Links: LabMedica
Subscribe to our newsletter to receive news, updates, and another stuff by email.