Human Papilloma Virus (HPV) | Hybribio
Human Papilloma Virus (HPV)
The Trigger of Cervical Cancer Human Papilloma Virus (HPV) is one of the most common sexually transmitted disease. It has been confirmed by WHO in 1996 as a major role in developing cervical cancer (CC), the second most common cancer among women worldwide. According to a statistic from WHO published in 2010, an estimated number of 280,000 death and 530,000 new cases due to CC were reported.
Reference: Human Papillomavirus and Related Cancers
21 HPV GenoArray Diagnostic Kit
21 HPV GenoArray Diagnostic Kit
Being an expert in
Cervical Intraepithelial Neoplasia Diagnosis
(HBGA-21PKG)
Summary
Rapid & accurate HPV genotyping macro array for 21 human papillomavirus identification
Features
15 high-risk HPV types: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68
6 low-risk HPV types: HPV 6, 11, 42, 43, 44, 81 (CP8304)
High sensitivity and specificity: >95% (compared to FDA approved kit)
Promising results compared to Roche’s Linear Array; with a better detection of HPV 52
Amplification control (IC) and hybridization control (Biotin) for the monitoring of the entire process
Cell Lysis Kit is included for DNA extraction
Workflow
Sample Collection Medium
Hybribio Female Sample Collection Kit (HBCK-F)
Liquid-based cytology system (e.g. ThinPrep® – Hologic, SurePathTM – BD, etc.)
Specification
Reference code: HBGA-21PKG
No. of Tests per kit: 30
Analytes: 15 high-risk HPVs and 6 low-risk HPVs
Sample type: Cervical or Urine Sample
Device/instrument required: Thermal Cycler and HybriMax®
Sample volume required: 1 ml
Controls: Internal Control (PCR amplification), Biotin (Hybridization)
Maximum run at a time: 15 tests (including positive control and negative control)
Result: 21 HPV genotyping; single and multiple infections
Schematic Diagram for HPV Genotyping results
37 HPV GenoArray Diagnostic Kit
37 HPV GenoArray Diagnostic Kit
Rapid HPV Genotyping MarcoArray
(HBGA-37PKG)
Summary
Rapid & accurate HPV genotyping macro array for 37 human papillomavirus identification
Features
15 high-risk HPV types: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68
6 low-risk HPV types: HPV 6, 11, 42, 43, 44, 81 (CP8304)
16 undetermined HPV types: HPV 26, 34, 40, 54, 55, 57, 61, 67, 69, 70, 71, 72, 73, 82, 83, 84
High sensitivity and specificity: >95% (compared to SFDA approved kit & sequencing)
Amplification control (IC) and hybridization control (Biotin) for the monitoring of the entire process
Cell Lysis Kit is included for DNA extraction
Workflow
Sample Collection Medium
Hybribio Female Sample Collection Kit (HBCK-F)
Liquid-based cytology system (e.g. ThinPrep® – Hologic, SurePathTM – BD)
Specification
Reference code: HBGA-37PKG
No. of Tests per kit: 30
Analytes: 15 high-risk HPVs, 6 low-risk HPVs & 16 undetermined HPVs
Sample type: Cervical or Urine Sample
Device/instrument required: Thermal Cycler and HybriMax®
Sample volume required: 1 ml
Controls: Internal Control (PCR amplification), Biotin (Hybridization)
Maximum run at a time: 15 tests (including positive control and negative control)
Result: 37 HPV genotyping; single and multiple infections
Schematic Diagram for HPV Genotyping results
14 High-risk HPV with 16/18 Genotyping Real-time PCR Kit
14 High-risk HPV with 16/18 Genotyping Real-time PCR Kit
(HBRT-H14)
Summary
The most cost-effective HPV real-time PCR kit for Cervical Cancer screening
Features
14 high-risk HPV types: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68
Specific Detection of 2 high-risk HPV genotypes: HPV 16 & HPV 18
High sensitivity and specificity: >95% (compared to SFDA approved kit)
Cellular IC for the monitoring of the entire process
Workflow
Sample Collection Medium
Hybribio Female Sample Collection Kit (HBCK-F)
Liquid-based cytology system (e.g. ThinPrep® – Hologic, SurePathTM – BD)
Specification
Reference code: HBRT-H14
No. of Tests per kit: 48
Analytes: A group of 12 high-risk HPVs, 16 and 18
Sample type: Cervical Sample
Device/instrument required: 4 channel Real-time PCR machine (Probes: FAM, HEX/JOE, ROX/ Red 610, Cy5)
Sample volume required: 1 ml
Controls: Internal Controls (IC), External Controls
Maximum run at a time: 48 tests / 96 tests (including positive and negative controls)
Result: Quantitative detection of 14 High Risk HPV types, typing of HPV 16 and HPV 18, suitable for single and multiple infections
Benefits
High throughput with short reaction time
Easy to operate
No specific RT-PCR instrument required, open platform
Triage and management of patients with ASCUS & LSIL
Reduce unnecessary labor cost and reaction time
Result Example of 13 High-risk HPV Real-time PCR Kit
13 High-risk HPV Real-time PCR Kit
13 High-risk HPV Real-time PCR Kit
(HBRT-H13C)
Summary
Ideal Kit for Primary Cervical Cancer Screening
Features
13 high-risk HPV types: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68
High sensitivity and specificity: >95% (compared to FDA approved kit)
Cellular IC for the monitoring of the entire process
Workflow
Sample Collection Medium
Hybribio Female Sample Collection Kit (HBCK-F)
Liquid-based cytology system (e.g. ThinPrep® – Hologic, SurePathTM – BD)
Specification
Reference code: HBRT-H13C
No. of Tests per kit: 48
Analytes: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68
Sample type: Cervical Sample
Device/instrument required: 2 channel Real-time PCR instrument
Detector FAM & HEX
Sample volume required: 1 ml
Controls: Internal Controls (IC), External Controls
Maximum run at a time: 96 tests (including positive and negative controls)
Result: Quantitative detection of 13 High Risk HPV types
Benefits
High throughput with short reaction time
Easy to operate
No specific RT-PCR instrument required, open platform
Triage and management of patients with ASCUS & LSIL
Reduce unnecessary labor cost and reaction time
Result Example of 13 High-risk HPV Real-time PCR Kit
5 Low-risk HPV Real-time PCR Kit
5 Low-risk HPV Real-time PCR Kit
(HBRT-L5)
Summary
The fast and efficient test to detect the cause of HPV genital warts
Features
5 low-risk HPV types: HPV 6, 11, 42, 43, 44
High sensitivity and specificity: >95% (compared to SFDA approved kit)
Cellular IC for the monitoring of the entire process
Compatible to most RT- PCR instruments with FAM and HEX reporter channels such as Roche and ABI
Workflow
Sample Collection Medium
Hybribio Female Sample Collection Kit (HBCK-F)
Liquid-based cytology system (e.g. ThinPrep® – Hologic, SurePathTM – BD)
Specification
Reference code: HBRT-L5
No. of Tests per kit: 48
Analytes: HPV 6, 11, 42, 43, 44
Sample type: Cervical Sample
Device/instrument required: 2 channel Real-time PCR instrument
Detector FAM & HEX
Sample volume required: 1 ml
Controls: Internal Controls (IC), External Controls
Maximum run at a time: 96 tests (including positive and negative controls)
Result: Quantitative detection of 5 Low Risk HPV types suitable for single and multiple infection
Benefits
High throughput with short reaction time
Easy to operate
No specific RT-PCR instrument required, open platform
Reduce labor cost
Result Example of 5 Low-risk HPV Real-time PCR Kit Detection