GastroPanelPepsinogen I ELISA, Pepsinogen II ELISA, Gastrin-17 ELISA, Helicobacter pylori IgG ELISA
The test panel consists of four assays:GastroPanel® is a simple laboratory examination performed on a blood sample. It gives diagnosis, for example, of healthy stomach mucosa, Helicobacter pylori (H.pylori) infection and atrophic gastritis. Based on the results, functional dyspepsia can be differentiated from organic dyspepsia. The results also give important information on possible risks related to H.pylori infection, atrophic gastritis and high acid production. GastroPanel examination promotes evidence-based medicine. H.pylori infection is diagnosed by an antibody test. Pepsinogen I, pepsinogen II and gastrin-17 levels describe the structure and function of the whole gastric mucosa. The more severe is the atrophic gastritis in the corpus mucosa, the lower is the level of pepsinogen I, and the ratio of pepsinogenI/II in blood. The more severe is the atrophic gastritis of antrum mucosa, the lower is the the level of gastrin-17 in blood. GastroPanel® gives a reliable diagnosis of:Healthy stomach mucosa. When the stomach mucosa is healthy, the reason for stomach problems is most likely to be functional dyspepsia or disease outside the stomach.
Test results and diagnosisReference ranges and explanation on values outside them Recommendations for further testing/treatment (e.g. gastroscopy and biopsy examination, H.pylori eradication treatment) that the doctor in charge decides on. GastroPanel® is well suited for follow-up of the success of treatment for H.pylori eradication treatment and atrophic gastritis, as well as for their diagnosis. Furthermore, Gastrin-17 level indicates whether the patient may have hyperacidic stomach, and a resulting risk of gastroesophageal reflux disease (GERD) and its complications. GastroPanel can therefore be used to determine whether a patient really needs e.g. commonly described PPI (proton pump inhibitor) medication. If a patient has atrophic gastritis in the corpus, the stomach is hypoacidic, and there is no need for PPIs; if the stomach is hyperacidic, the situation is different.
Table above In a Finnish multicenter study with 404 dyspepsia patients as participants, the performance of GastroPanel was compared to histology. GastroPanel examination diagnosed healthy stomach mucosa nearly as reliably as gastroscopy and biopsy examination. For atrophic gastritis, the accuracy was excellent (81%) compared to histological study. The Quality Management System of Biohit has been awarded with the ISO 9001 and the ISO 13485, as well as the ISO 14001. |