Throughput: 480 tests/hour 580 tests/hour with ISE
Test items on board: 36 items + ISE 3 items
Reaction volume: 120– 300 micro-liter
Patient samples on board: 72 patient samples, 30 STAT samples
Reaction volume: 140– 300 micro-liter
Test items on board: 24 items + ISE 3 items / 36 items + ISE 3 items
Patient samples on board: 30 patient samples
Throughput: 270 tests/hour 450 tests/hour with ISE
R1: 140 ～ 300μl (1μl step）
R2: 20 ～ 260μl (1μl step）
News and Announcements
Cardiovascular disease generally refers to conditions that involve narrowed or blocked blood vessels that can lead to a heart attack, chest pain (angina) or stroke. Cardiovascular disease (CVD) risk prediction represents an increasing clinical challenge in the treatment of diabetes.
A panel of vascular imaging, functional assessments, and biomarkers reflecting different disease mechanisms has been used to identify clinically useful markers of risk for cardiovascular (CV) events in subjects with type 2 diabetes (T2D) with or without manifest CVD. A team of scientists led by those at the University of Exeter (Exeter, UK) recruited 936 subjects with T2D at four European centers. Carotid intima-media thickness and plaque area, ankle-brachial pressure index, arterial stiffness, endothelial function, and circulating biomarkers were analyzed at baseline, and CV events were monitored during a three-year follow-up period.
The investigators reported that the CV event rate in 440 subjects with T2D was statistically higher in those with than in those 496 without manifest CVD at baseline (5.53 versus 2.15/100 life-years). New CV events in subjects with T2D with manifest CVD were associated with higher baseline levels of inflammatory biomarkers such as interleukin 6, chemokine ligand 3, pentraxin 3, and high sensitivity C-reactive protein (hs-CRP) and endothelial mitogens represented by, hepatocyte growth factor and vascular endothelial growth factor A. However, CV events in subjects with T2D without manifest CVD were associated with more severe baseline atherosclerosis (median carotid plaque area 34.5 mm2 versus 19.5 mm2. Conventional risk factors, as well as measurements of arterial stiffness and endothelial reactivity, were not associated with CV events.
The authors concluded that their observations demonstrate that markers of inflammation and endothelial stress reflect CV risk in subjects with T2D with manifest CVD, whereas the risk for CV events in subjects with T2D without manifest CVD is primarily related to the severity of atherosclerosis. The study was published on July 6, 2018, in the journal Diabetes Care.LabMedica
Obstructive sleep apnea is a disorder in which breathing is repetitively interrupted during sleep due to collapse of the upper airway. An apnea is defined as complete cessation of breathing lasting 10 seconds or greater.
Dyslipidemia is an abnormal amount of lipids such as triglycerides, cholesterol and/or fat phospholipids in the blood. Both obstructive sleep apnea (OSA) and dyslipidemia are independent risk factors for cardiovascular disease.
An international team of investigators led by scientists at the Sahlgrenska Academy (Gothenburg, Sweden) carried out a cross‐sectional analysis that included 8,592 patients without physician‐diagnosed hyperlipidemia or reported intake of a lipid‐lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnea–hypopnea index (AHI): 25.7 ± 25.9 events/hour). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high‐density was calculated.LabMedica
In the developing world, the manufacture and the distribution of substandard, non-legitimate medicines is widespread. It has been estimated that up to 10% of all drugs worldwide could be falsified with up to 50% of those some form of antibiotics
When a prescription is filled at the doctor"s office or pharmacy today, mostly it is taken for granted that these commonly prescribed medicines are real, and of good quality. A counterfeit or diluted antibiotic cannot only endanger an unwitting patient, but can also contribute to the wider problem of antimicrobial resistance
Biochemists at the Colorado State University (Fort Collins, CO, USA) have created a paper-based test that can quickly determine whether an antibiotic sample is appropriate strength, or diluted with filler substances like baking soda. Similar to the mechanism of a home pregnancy test, a strip of paper turns a distinctive color if a falsified antibiotic is present. The test is based on the fact that bacteria naturally produce an enzyme that can give them resistance to antibiotics by chemically binding to portions of the antibiotic molecule. The team used this very enzyme, called beta-lactamase, to empower their device to detect the presence of antibiotics in a given sample.LabMedica
Stanford University School of Medicine researchers have demonstrated that gene therapy can be effective without causing a dangerous side effect common to all gene therapy: an autoimmune reaction to the normal protein, which the patient"s immune system is encountering for the first time.ing during gestation allows early antenatal detection and rapid treatment initiation, with economic and patient outcome benefits.
The researchers showed this in a mouse model that accurately recapitulates Duchenne muscular dystrophy. One in every 5,000 boys is born with this crippling disease, which leaves patients wheelchair-bound by mid-adolescence and is typically fatal by young adulthood. It stems from a genetic defect that deprives skeletal and cardiac muscles of a working version of a protein called dystrophin.
"Gene therapy is on the cusp of becoming a mainstream approach for treating single-gene disorders," said Lawrence Steinman, MD, professor of neurology and neurological sciences and of pediatrics at Stanford. "But there"s a catch: If you give a gene that"s a recipe for a normal protein to someone with a faulty version of the gene, whose body never made the normal protein before, that person"s immune system will mount a reaction __ in some cases, a lethal one __ to the normal protein, just as it would to any foreign protein. We think we"ve solved that problem."Read more here
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